Description
Product Characteristics:
Aliases: IMDH2_HUMAN antibody, IMP (inosine monophosphate) dehydrogenase 2 antibody, IMP dehydrogenase 2 antibody, IMP oxireductase 2 antibody, IMPD 2 antibody, IMPD2 antibody, IMPDH 2 antibody, IMPDH II antibody, IMPDH-II antibody, Impdh2 antibody, Inosine 5' monophosphate dehydrogenase 2 antibody, Inosine 5' phosphate dehydrogenase 2 antibody, Inosine monophosphate dehydrogenase type II antibody, Inosine-5''-monophosphate dehydrogenase 2 antibody
Target Information: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]